Hollywood’s glamour universe runs on image. In recent years, some celebrities who made a career out of body positivity or confronted fat-phobia, now openly admit to using Ozempic or other GLP‑1 medications. This trend raises major questions about culture, health, and image.

Oprah Winfrey

Oprah publicly admitted to using a weight-loss drug. She said it spread “relief, redemption, a gift.” Oprah revealed the drug changed how she saw thinness, shattering myths about willpower and hunger control. She now uses it to manage “food noise” and maintain weight.

Rebel Wilson: From Plus-Size Icon to Ozempic Ally

Rebel Wilson became famous as “Fat Amy” in Pitch Perfect. She established a brand on confidence, inclusivity, and defying body-image norms. Celebrated her curves and asserted that size did not hinder her. Then proclaimed an 80-pound weight loss project, and her career changed direction.

Rebel occasionally resorted to Ozempic to suppress cravings following initial dieting triumph. She revealed it enabled her to break free from stereotypical comic character roles and do more dramatic ones. However, she continues promoting body acceptance and asserts healthy options are more important than looks.

Lizzo: Freedom, Fitness and a Whiff of Ozempic

Lizzo emerged as a force for self-love. Her message and music honour all bodies. She explained in interviews that her weight loss in recent years had resulted from exercise, diet, and overall wellness, not magic pills.

That changed when she confessed to attempting Ozempic during a push for weight loss. She maintained that if it made her feel good and her reflux was better, she wouldn’t judge others for using it. She branded critics as fat-phobic and asserted well-being over thinness.

Kathy Bates: The Surprising Ozempic Admission

Kathy Bates employs her celebrity status to fight against age and weight discrimination. She’s openly borne her larger body all her life. But she did openly discuss using Ozempic. She lost 80 pounds through lifestyle efforts, then lost a further 20 with the assistance of medication.

She emphasised that despite medication, there was still discipline required for forward movement. Her experience highlights a transformation, even mythical icons of natural body acceptance are adopting new medical technologies.

Perez Hilton: From Critic to Champion

Celebrity blogger Perez Hilton once mocked weight-loss drugs. He later changed. After losing over 60 pounds, he now praises GLP‑1 meds as legitimate tools when paired with diet and exercise. He urges people to ditch the stigma and talk openly about their use.

Tracy Morgan: Male Voice in the Mix

Comedian Tracy Morgan started using Ozempic in 2023. He joked about gaining and then controlling weight, but ultimately confirmed it helped curb appetite. He calls it a health tool, not a vanity fix.

Ice Spice: Denial Sparks Controversy

Ice Spice skyrocketed as a full-bodied rapper who dismissed size-related rumours. Isis Naija Gaston underwent a striking transformation, and rumours swirled about Ozempic. She responded with video proof, lifting, stretching, doing splits in training, to claim it’s all gym work. She rejected Ozempic publicly.

What Changed?

These stars were once poster children for body diversity. Rebel and Lizzo were also vocal about pushing against societal expectations and celebrating extreme self-love. Now, they are talking about Ozempic openly. Some fans are disappointed. Others view this as evolution, not regression.

Health: To many, they used Ozempic to regulate conditions such as reflux, diabetes, or emotional overeating.

Image: Some embraced roles that fit their own skinnier selves.

Honesty: They think being open outweighs keeping drug use hidden.

Their turnaround also highlights the way Hollywood creates beauty standards. Even icons of abundance feel they must conform to script, camera, or casting. Their embracing of Ozempic indicates a larger cultural reboot.

The Bigger Message

These tales highlight the spotlight Ozempic has gained in Hollywood. The medication might address health and self-esteem, but it comes with risks, too. Loose skin, mood changes, and stigma are not uncommon. Experts have emphasised that medical supervision is important. But Hollywood’s glare has already redefined Ozempic from taboo to tool.

Fans today wonder: Did the stars alter values, or did culture alter around them? For a moment, they are still champions of candour and nuance. They demonstrate that even renowned champions of body positivity can adapt to new realities and that the boundary between self-love and cultural pressure remains indeterminate.

Hollywood’s most outspoken body-positive celebrities now talk openly about Ozempic. Rebel Wilson, Lizzo, and Kathy Bates are at the top of that list. They combine empowerment with vulnerability. Their stories touch on health, image, and decision. They defy simplistic labels. And they remind us that body positivity isn’t about one size. It’s about freedom to love, accommodate, and be real.

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